High-risk category • Prosthetic cardiac valves, including both bioprosthetic and homograft valves • Previous bacterial endocarditis • Complex cyanotic congenital heart disease (e.g., single ventricle states, transposition of the great arteries, tetralogy of Fallot) • Surgically constructed systemic pulmonary shunts or conduits Moderate-risk category • Most congenital cardiac malformations other than above and below (see next question) • Acquired valvular dysfunction (e.g., rheumatic heart disease) • Hypertrophic cardiomyopathy • Mitral valve prolapse with valvular regurgitation and/or thickened leaflets
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